Pathophysiological aspects of renal stone formation and stone types

نویسندگان

چکیده

Urinary stone formation is one of the oldest and most widespread diseases known to man. The disease has a multifactorial etiology that includes anatomic, environmental, genetic, infectious, metabolic, nutritional, importantly socio-economic factors. It caused by biochemical imbalance in urine between stone-forming inhibitors promotors process as lithogenesis. mechanisms underlying development urinary stones are not fully understood, but it can be said they generally begin increased supersaturation lithiasis promoters urine, followed nucleation aggregation. Subsequently, crystals combine with other solution form agglomerates accumulate kidney. Free radical-mediated oxalate-induced renal membrane damage promotes crystal retention at surface papilla, well lower levels. In addition, type identification great interest guiding physician an effective diagnosis, which allows determine causes order treat prevent recurrence. this context, present study reviews current knowledge on pathophysiological aspects kidney stones.

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ژورنال

عنوان ژورنال: Notulae Scientia Biologicae

سال: 2023

ISSN: ['2067-3264', '2067-3205']

DOI: https://doi.org/10.55779/nsb15111462